GLP-TZ 20mg | NeuroPept Labs

Description

GLP-TZ (tirzepatide, LY3298176), also listed as GLP-2TZ, is a synthetic 39-amino acid research peptide characterised as a dual GIP and GLP-1 receptor agonist — a molecular class termed “twincretin” — engineered to engage both the gastric inhibitory polypeptide receptor (GIPR) and the glucagon-like peptide-1 receptor (GLP-1R) through a single peptide backbone. This bispecific receptor engagement distinguishes it from monoagonist GLP-1 compounds in incretin receptor pharmacology research.

NeuroPept Labs supplies GLP-TZ 20mg as a research-grade lyophilized peptide intended strictly for in vitro laboratory and analytical research use. All batches are manufactured under controlled synthesis conditions and verified through third-party analytical testing. COA validity can be confirmed at freedomdiagnosticstesting.com using the Accession Number, Client ID, or Search Code found in the product images.

GLP-TZ, GLP-2TZ and “TZ Peptide”: One Compound

GLP-TZ is the NeuroPept Labs catalogue name for tirzepatide (LY3298176). Other suppliers list the same compound as GLP-2TZ, GLP-2 TZ or simply TZ peptide. All of these names refer to the same 39-amino-acid dual GIP/GLP-1 receptor agonist. The identity result on a batch’s COA (LC-MS) is how a laboratory confirms what a vial contains.

Mechanism of Action (Research Overview)

GLP-TZ’s molecular design is based on the native GIP sequence, with modifications enabling GLP-1R co-agonism and a C20 fatty diacid moiety studied for albumin binding and extended plasma residence in the published literature. Receptor-level properties characterised in vitro include:

• GIP Receptor (GIPR) — incretin receptor coupled to Gs signalling; GIPR is highly expressed in white adipose tissue, and GLP-TZ’s GIPR agonism is studied in adipocyte lipid-handling and adipokine-signalling models.
• GLP-1 Receptor (GLP-1R), biased agonism — in receptor-signalling assays GLP-TZ preferentially activates cAMP/Gs over ?-arrestin recruitment, a property that differentiates it from native GLP-1 at the receptor level and is an active subject of in vitro pharmacology research.
• Dual-receptor co-activation — engagement of GIPR and GLP-1R through one molecule is studied in cell-based assays characterising combined incretin receptor signalling and cross-talk.

Receptor binding affinities and functional potency data are reported in the peer-reviewed sources cited below.

GLP-TZ (Tirzepatide) vs Semaglutide vs GLP-3RT (Retatrutide)

The three most-studied incretin-class research peptides differ in receptor profile:

NeuroPept Labs also supplies GLP-3RT 10mg and GLP-3RT 30mg for researchers studying the full spectrum of GLP-1/GIP/glucagon receptor agonism.

Research Significance

The material supplied by NeuroPept Labs is a research-use-only reference compound for in vitro laboratory work — it is not a pharmaceutical product and is not approved for human or veterinary use. Published areas of laboratory investigation include:

• Incretin biology and dual receptor (GIPR/GLP-1R) pharmacology
• Biased agonism characterisation at GLP-1R (cAMP/Gs vs ?-arrestin)
• Beta-cell and pancreatic islet signalling models in vitro
• Adipocyte lipid-handling and adipokine signalling models
• Peptide structure–activity relationship studies
• Analytical method development and reference-standard characterisation

Buy GLP-TZ 20mg: Tirzepatide Peptide for Research

GLP-TZ is the tirzepatide peptide for sale at NeuroPept Labs, also listed by other suppliers as GLP-2TZ. It comes as a single 20mg vial of lyophilized research peptide for in vitro laboratory work. Each lot is tested by Freedom Diagnostics for HPLC purity and LC-MS identity; the batch-specific COA for the current lot is in our COA Library. Orders are supplied to qualified researchers and institutions only, and the material is not for human or veterinary use.

• What you receive: one vial, 20mg GLP-TZ (tirzepatide), lyophilized
• Purity and identity: >99% by HPLC, identity confirmed by LC-MS
• Documentation: batch-specific COA, verifiable at freedomdiagnosticstesting.com

GLP-TZ 20mg Product Specifications

Storage and Handling

• Store lyophilized peptide at -20°C or below prior to reconstitution
• Avoid repeated freeze-thaw cycles to preserve structural integrity
• Protect from direct light, humidity, and room temperature exposure
• Reconstitute using appropriate sterile laboratory solvents under aseptic conditions
• Once reconstituted, store at 4°C and use within recommended research timeframes

Frequently Asked Questions

What is GLP-TZ (tirzepatide)?

GLP-TZ is the NeuroPept Labs catalogue name for tirzepatide (LY3298176), a synthetic 39-amino acid research peptide and dual GIP/GLP-1 receptor agonist — a molecular class termed “twincretin”. It is studied in vitro for dual incretin receptor pharmacology, biased agonism at GLP-1R, and peptide structure–activity relationships. It is also listed by some suppliers as GLP-2TZ.

Is GLP-TZ the same as GLP-2TZ?

Yes. GLP-2TZ, GLP-2 TZ and TZ peptide are other suppliers’ names for tirzepatide, which NeuroPept Labs lists as GLP-TZ. The batch-specific COA confirms identity by LC-MS.

What makes GLP-TZ a “biased agonist” at GLP-1R?

In receptor-signalling studies, GLP-TZ preferentially activates the cAMP/Gs pathway over ?-arrestin recruitment at GLP-1R. This receptor-level property differentiates it from native GLP-1 and from other GLP-1R agonists and is an active area of in vitro pharmacology research.

How does GLP-TZ compare to GLP-3RT (retatrutide)?

GLP-TZ is a dual GIP/GLP-1 receptor agonist. GLP-3RT (retatrutide) adds a third target, the glucagon receptor (GCGR), engaging hepatocyte-expressed receptor signalling not addressed by GLP-TZ’s dual profile. Both are available from NeuroPept Labs for comparative incretin receptor pharmacology research.

Is GLP-TZ (tirzepatide) approved for human use?

No. The material supplied by NeuroPept Labs is a research-use-only reference compound for in vitro laboratory work. It is not a pharmaceutical product, is not the clinical product, and is not approved for human consumption, medical treatment, or veterinary use.

Where can I buy tirzepatide (GLP-TZ) research peptide?

GLP-TZ 20mg (tirzepatide) is sold directly by NeuroPept Labs at neuropeptlabs.com for in vitro laboratory research use. Each lot has batch-specific Certificate of Analysis documentation, published in the COA Library, and material is supplied to qualified researchers and institutions only.

What purity is NeuroPept Labs’ GLP-TZ 20mg?

Our GLP-TZ 20mg research peptide is supplied at >99% purity, verified by HPLC and third-party analytical testing. COA documentation is available for every batch and can be verified at freedomdiagnosticstesting.com.

How do I verify the Certificate of Analysis?

Each batch is tested by an independent third-party laboratory. COA validity can be confirmed at freedomdiagnosticstesting.com using the Accession Number, Client ID, or Search Code shown in the product images.

How should GLP-TZ 20mg be stored?

Store the lyophilized peptide at -20°C or below, away from direct light and moisture. Avoid repeated freeze-thaw cycles. Once reconstituted, store at 4°C and use within recommended laboratory timeframes.

Scientific References

1. Tirzepatide Is an Imbalanced and Biased Dual GIP and GLP-1 Receptor Agonist — PMC / NIH 2020
2. Unveiling Tirzepatide’s Spectrum: A Dual GIP/GLP-1 Review — PMC / NIH 2025
3. Insights into the Mechanism of Action of Tirzepatide — PMC / NIH 2025