Selank 10mg | NeuroPept Labs

Selank 10mg is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) and a stabilized analog of the endogenous immunopeptide tuftsin, studied as an anxiolytic, nootropic, and neuroimmune research compound. NeuroPept Labs supplies Selank as a research-grade lyophilized powder at >99% HPLC-verified purity, intended strictly for in vitro laboratory research.

What Is Selank?

Selank is a seven-amino-acid regulatory peptide created by attaching a stabilizing Pro-Gly-Pro tripeptide to the Thr-Lys-Pro-Arg sequence of tuftsin, a naturally occurring immunomodulatory tetrapeptide. This modification confers markedly greater resistance to enzymatic degradation than native tuftsin, giving it a longer functional window in research models. It is investigated as a multi-target peptide rather than a single-receptor ligand, with reported activity spanning the GABAergic, neurotrophic, enkephalinergic, and neuroimmune systems. Throughout the scientific literature it is handled as a research-use-only material.

Selank Mechanism of Action (Research Only)

Current understanding of the peptide is derived from preclinical and limited clinical research and should be interpreted strictly in an experimental context. Reported mechanisms include:

GABAergic Modulation

Clinical and gene-expression studies report that Selank produces an anxiolytic profile comparable to classical benzodiazepines, consistent with allosteric modulation of GABA-A receptor mediated neurotransmission. In rodent models it alters the expression of numerous genes governing GABAergic signalling without the sedation, cognitive impairment, or dependence markers associated with benzodiazepines.

BDNF and Neuroplasticity

It has been reported to rapidly elevate brain-derived neurotrophic factor (BDNF) expression in the hippocampus, a pathway associated with synaptic remodelling and durable behavioural effects in stress models.

Enkephalinergic Signalling

It slows the enzymatic degradation of endogenous enkephalins by inhibiting enkephalin-degrading enzymes, prolonging the availability of these opioid peptides. This mechanism is studied in the context of stress-response and anxiety research.

Neuroimmune and Cytokine Regulation

Reflecting its tuftsin-derived lineage, it modulates the expression of inflammation- and immune-related genes and influences interferon and cytokine profiles, making it a tool for neuroimmunology research.

Selank Research Applications (Observations from Studies)

Anxiolytic and Behavioural Research

It is used in elevated-plus-maze, chronic-stress, and related paradigms to study benzodiazepine-comparable anxiolytic activity without classical sedation or dependence signatures.

Nootropic and Neuroplasticity Research

Attention, memory-consolidation, and executive-function endpoints are examined through BDNF-linked neuroplasticity pathways.

Neuroimmunology

The cytokine- and interferon-modulating activity inherited from the tuftsin pharmacophore is studied in immune-signalling models.

Combination Peptide Pharmacology

It is co-investigated with GABAergic agents and with the related peptide Semax to study complementary neuromodulatory pathways.

Selank vs. Semax vs. Noopept

Researchers frequently compare it with other regulatory and nootropic compounds. The table below summarizes their distinctions in a research-only context.

Product Specifications

Certificate of Analysis (COA) & Quality Assurance

Every batch is synthesised under controlled conditions and verified through third-party analytical testing, including HPLC purity analysis and mass-spectrometry identity confirmation. A batch-specific Certificate of Analysis is available for each lot, and COA validity can be independently confirmed at freedomdiagnosticstesting.com using the Accession Number, Client ID, or Search Code shown in the product images.

Selank Laboratory Safety & Handling (Research Use Only)

Laboratory Handling Guidelines

This peptide should be handled only by qualified personnel following institutional standard operating procedures. Use appropriate personal protective equipment (gloves, lab coat, eye protection), work under aseptic conditions when reconstituting, and document all handling for traceability.

Storage and Stability Considerations

Store the lyophilized peptide at -20°C or below, protected from light and moisture, and avoid repeated freeze-thaw cycles to preserve structural integrity. After reconstitution with sterile bacteriostatic water, store at 4°C and use within recommended research timeframes.

Frequently Asked Questions

What is Selank?

Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from the endogenous immunomodulatory peptide tuftsin. It is studied as a regulatory peptide with anxiolytic, nootropic, and neuroimmune activity, acting across GABAergic, BDNF, and enkephalinergic pathways. It is supplied strictly as a research-use-only material.

What is Selank used for in laboratory research?

In laboratory and preclinical research, it is used as a tool compound to study anxiolytic mechanisms, including GABA-A receptor modulation, BDNF-driven neuroplasticity, enkephalinase inhibition, and neuroimmune (cytokine/interferon) signalling. It is not used for, or intended for, any human or veterinary application.

How is Selank different from Semax?

Both are Russian-developed regulatory heptapeptides ending in a stabilizing Pro-Gly-Pro sequence, and they are frequently studied side by side. It is a tuftsin analog studied primarily for anxiolytic and neuroimmune activity via GABAergic and enkephalinergic pathways, whereas Semax is an ACTH(4-10) analog studied primarily for nootropic and neuroprotective activity via BDNF/NGF and monoaminergic pathways.

What is the amino acid sequence of Selank?

Selank is a heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro — the tuftsin tetrapeptide (Thr-Lys-Pro-Arg) extended with a stabilizing Pro-Gly-Pro tripeptide (molecular formula C33H57N11O9, molecular weight 751.9 g/mol).

What purity is NeuroPept Labs’ Selank 10mg?

NeuroPept Labs Selank 10mg is supplied at >99% purity, verified by HPLC and third-party analytical testing. A Certificate of Analysis is available for every batch.

Does NeuroPept Labs provide a Certificate of Analysis (COA) for Selank?

Yes. Every batch ships with third-party HPLC and mass-spectrometry documentation. COA validity can be confirmed at freedomdiagnosticstesting.com using the Accession Number, Client ID, or Search Code shown in the product images.

How should Selank be stored and reconstituted?

Store the lyophilized peptide at -20°C or below, away from light and moisture, and avoid repeated freeze-thaw cycles. For research use it is reconstituted with sterile bacteriostatic water under aseptic conditions; once reconstituted, store at 4°C and use within recommended research timeframes.

Scientific References

1. Volkova A, et al. Frontiers in Pharmacology (2016) — Selank affects expression of genes involved in GABAergic neurotransmission. PMC / DOI 10.3389/fphar.2016.00031
2. Filatova E, et al. Frontiers in Pharmacology (2017) — GABA, Selank, and olanzapine affect GABAergic gene expression in IMR-32 cells. PMC / DOI 10.3389/fphar.2017.00089
3. Kolomin T, et al. Molecular Immunology (2014) — Temporal dynamics of inflammation-related gene expression under the tuftsin analog Selank. PubMed / DOI 10.1016/j.molimm.2013.11.002
4. Konstantinopolsky MA, et al. Bulletin of Experimental Biology and Medicine (2022) — Selank attenuates aversive signs of morphine withdrawal in rats. PubMed / DOI 10.1007/s10517-022-05624-x
5. Panikratova YR, et al. Doklady Biological Sciences (2020) — Functional connectomic approach to studying Selank and Semax effects. PubMed / DOI 10.1134/S001249662001007X

Research Use Disclaimer: All products sold by NeuroPept Labs are intended strictly for in vitro laboratory research and scientific investigation by qualified professionals. They are not approved for human consumption, medical treatment, or veterinary use. Purchasers are responsible for compliance with applicable regulations in their jurisdiction.