Semax 10mg | NeuroPept Labs

Semax 10mg is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) analogue of the ACTH(4-10) fragment, studied extensively as a neuroprotective and nootropic research compound. The Pro-Gly-Pro terminal extension confers resistance to enzymatic degradation, allowing Semax to influence neurotrophic and monoaminergic pathways without the corticotropic activity of the parent adrenocorticotropic hormone.

NeuroPept Labs supplies Semax 10mg as a research-grade lyophilized peptide intended strictly for in vitro laboratory and analytical research use. All batches are synthesised under controlled conditions and verified through third-party analytical testing. COA validity can be confirmed at freedomdiagnosticstesting.com using the Accession Number, Client ID, or Search Code found in the product images.

Semax Mechanism of Action (Research Overview)

Semax is investigated as a neurotrophic regulatory peptide with several reported research mechanisms:

• BDNF/TrkB upregulation — increases hippocampal brain-derived neurotrophic factor expression and TrkB receptor phosphorylation in rodent models
• NGF and neurotrophin signalling — modulates nerve growth factor expression relevant to neuronal survival and plasticity
• Monoaminergic modulation — influences dopaminergic and serotonergic tone linked to cognition and mood endpoints
• Neuroprotection under ischemia — studied for reduced neuronal damage and improved functional recovery in cerebral ischemia models
• Melanocortin lineage activity — retains a fragment of the ACTH sequence while lacking steroidogenic corticotropic effects

Research Applications

Current laboratory and preclinical investigation using the peptide spans multiple research domains:

• Nootropic and cognition research — learning, attention, and memory-consolidation endpoints driven by BDNF/TrkB signalling
• Neuroprotection and stroke research — ischemic and hypoxic injury models measuring neuronal survival and functional recovery
• Neurotrophic factor biology — BDNF and NGF expression dynamics in the hippocampus and cortex
• Neurodegeneration models — oxidative-stress and excitotoxicity paradigms
• Combination peptide pharmacology — co-investigation with Selank and other regulatory peptides

Product Specifications

Storage and Handling

• Store lyophilized peptide at -20°C or below prior to reconstitution
• Avoid repeated freeze-thaw cycles to preserve structural integrity
• Protect from direct light, humidity, and room temperature exposure
• Reconstitute using sterile bacteriostatic water under aseptic conditions
• Once reconstituted, store at 4°C and use within recommended research timeframes

Frequently Asked Questions

What is Semax?

It is a synthetic heptapeptide analogue of the ACTH(4-10) fragment, studied as a nootropic and neuroprotective research compound. It modulates the BDNF/TrkB neurotrophic system and monoaminergic signalling while lacking the corticotropic activity of the parent hormone.

How does Semax affect BDNF?

Research in rodent models reports that a single application of Semax increases hippocampal BDNF protein levels and TrkB receptor phosphorylation, with corresponding rises in BDNF and TrkB mRNA — a proposed basis for its cognitive and neuroprotective research effects.

Is Semax studied alongside Selank?

Yes. The two are complementary regulatory heptapeptides often examined together in nootropic and neuroprotective protocols, as they engage distinct but overlapping neurotrophic and neuromodulatory pathways.

What purity is NeuroPept Labs’ Semax 10mg?

Our Semax 10mg research peptide is supplied at 98% purity, verified by HPLC and third-party analytical testing. Full COA documentation is available for every batch and can be verified at freedomdiagnosticstesting.com.

Scientific References

1. Semax Regulates BDNF and TrkB Expression in the Rat Hippocampus | Brain Research 2006
2. Therapeutic Peptides: Current Applications and Future Directions | PMC/NIH 2022

Research Use Disclaimer: All products sold by NeuroPept Labs are intended strictly for in vitro laboratory research and scientific investigation by qualified professionals. They are not approved for human consumption, medical treatment, or veterinary use. Purchasers are responsible for compliance with applicable regulations in their jurisdiction.